https://nova.newcastle.edu.au/vital/access/ /manager/Index en-au 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:47745 Wed 25 Jan 2023 15:49:34 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:48347 Wed 15 Mar 2023 08:25:44 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30459 EG > PG > xylitol > fructose > sorbitol > mannitol > galactose > glucose > sucrose > maltitol.]]> Wed 04 Sep 2019 09:55:08 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:46993 Cu > Cd > Ni, despite electrostatic binding strength of Cd > Cu > Pb > Ni and covalent binding strength of Pb > Ni > Cu > Cd. It demonstrated that not only chemosorption but also physisorption acts as the sorption mechanism. The reduction in surface area, porosity, and pore volume of the expended adsorbent, along with sorption study results, confirmed that pore filling and intra-particle diffusion played a considerable role in removing heavy metals.]]> Tue 13 Dec 2022 09:56:24 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:37112 10 million patients with new cases diagnosed every year. The objective of this study was to prepare and evaluate erlotinib loaded chitosan nanoparticles for their anticancer potential. Also, to study the effect of various formulation variables on prepared nanoparticles using box-behnken design. Erlotinib loaded chitosan nanoparticles were prepared by ionic gelation method using the spray drying technique. It was found that batch SNP-9 has a maximum loading capacity (74.45 ± 0.34%) and entrapment efficiency (43 ± 0.57%) with a particle size 170.2 nm. Analysis of variance (ANOVA) was applied on the particle size, entrapment efficiency and % cumulative drug release to study the fitting and the significance of the model. The batch SNP-9 showed 89.46% and 40.12% drug release after 24 h in 0.1 N HCl and Phosphate Buffer (pH 6.8), respectively. The IC⁵⁰ value of SNP-9 evaluated on A549 Lung cancer cells was found to be 4.41 μM. The optimized formulation was found stable after the six-month study as no considerable transformation was detected. The optimized formulation released erlotinib slowly in comparison to the marketed tablet formulation. Erlotinib loaded chitosan nanoparticles were prepared successfully using spray drying technique with suitable particle size, entrapment efficiency, drug release. The synthesized and optimized nanoparticles were found to possess activity against cancer cells when evaluated in-vitro.]]> Thu 09 Dec 2021 11:02:22 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30061 Sat 24 Mar 2018 07:31:19 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30865 Phlogacanthus thyrsiformis used in culinary recipes in the north eastern India are also widely used as a folklore medicine for the treatment of kidney stones and liver disorders. The aim of this study was to evaluate the prophylactic and therapeutic activity of the aqueous extract of P. thyrsiformis flowers and its biofabricated silver nanoparticles against struvite urinary stones and calcium oxalate kidney stones. A kidney stone inhibition study was carried out on struvite stones grown in gel medium and calcium oxalate stones in rat models using an aqueous extract of P. thyrsiformis flowers and its biofabricated silver nanoparticles. The aqueous extract of P. thyrsiformis flowers and their biofabricated silver nanoparticles, obtained by a green synthetic method, were used to treat struvite urinary stones in vitro and calcium oxalate kidney stones in vivo. Struvite stones were grown in tubes by gel diffusion technique and were treated with varying concentrations of the extract and its nanoparticles. The size of the struvite stones was monitored for 96 h using a travelling microscope. Calcium oxalate stones were induced in male Wistar rats by feeding ethylene glycol-ammonium chloride mixture for 14 days. Both, prophylactic and therapeutic activities were evaluated by analyzing the urine, serum and histopathological parameters of the rats. The qualitative screening of water extract unveiled the presence of flavonoids as a major constituent. Both, the extract and the nanoparticles effectively reduced the size of struvite stones in vitro and eliminated calcium oxalate stones in Wistar rats in vivo. The potent therapeutic activity of both extract and silver nanoparticles was observed as compared to preventive activity. Anti-urolithiatic potency can be attributed to the presence of flavonoids.]]> Sat 24 Mar 2018 07:26:37 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:32348 Fri 25 May 2018 13:33:01 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:51958 Fri 22 Sep 2023 17:04:44 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:35108 Fri 21 Jun 2019 10:04:57 AEST ]]>